Chondrogenetic properties of the synovial tissue and a review of the literature on synovial mesenchymal stromal cells
The cartilage pathologies have been frequently seen in clinics. If they are not treated properly,
they may cause significant functional disabilities and may even finally progress to osteoarthritis of the
affected joint. There are various methods, which have been described for their treatment. The use of
mesenchymal stromal cells has been intensively studied for their differentiation to chondrocytes. There are also a variety of enhancing factor involved in this process. This study demonstrated that the synovial tissue is a highly suitable in-vivo culture for the growth of native articular cartilage tissue, especially involving subchondral bone -osteochondral tissues-. This intimate relationship between the synovial and hyaline cartilage tissues –which we prefer to call “biological tropism”- may open new frontiers on the treatment of cartilage lesions as an alternative “biological treatment”. Human can produce his own hyaline cartilage via synovial command and induction.
