Circulating vaspin and its relationship with insulin sensitivity, adiponectin, and liver histology in subjects with non-alcoholic steatohepatitis.

Doç. Dr. Halil Genç
Doç. Dr. Halil Genç
23 Temmuz 201860 görüntülenme
Randevu Al
Circulating vaspin and its relationship with insulin sensitivity, adiponectin, and liver histology in subjects with non-alcoholic steatohepatitis.

Circulating vaspin and its relationship with insulin sensitivity, adiponectin, and liver histology in subjects with non-alcoholic steatohepatitis.

Genc H, et al. Scand J Gastroenterol. 2011.

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Abstract

OBJECTIVE: Non-alcoholic steatohepatitis (NASH) is closely associated with components of metabolic syndrome. Vaspin is a novel adipocytokine that may link obesity, insulin resistance (IR), and type 2 diabetes mellitus. We aimed to investigate circulating vaspin levels in subjects with NASH and also to search for the association of vaspin with IR, adiponectin, and histological findings.

MATERIAL AND METHODS: A total of 50 male patients with NASH and 30 healthy male controls were enrolled. Vaspin and adiponectin were measured with ELISA method. Insulin sensitivity determined by homeostasis model assessment (HOMA-IR) index.

RESULTS: Plasma vaspin levels were higher and adiponectin levels were lower in NASH group compared with controls (p < 0.01 and p < 0.001, respectively). However, in multivariate analysis adjusted for glucose and lipid parameters, and HOMA-IR indexes, the difference in vaspin concentrations was disappeared. Nonetheless, the difference regarding the adiponectin levels remained significant between groups (p = 0.03). Vaspin was negatively correlated with low-density lipoprotein cholesterol (r = -0.32, p = 0.03) in subjects with NASH.

CONCLUSIONS: This study indicates that circulating vaspin levels are not altered in male subjects with NASH. These results suggest that in the absence of metabolic risk factors, vaspin per se may not be involved in the pathogenesis of NASH.

PMID

 21770819 [Indexed for MEDLINE]

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Doç. Dr. Halil Genç

Doç. Dr. Halil Genç

Doç. Dr. Halil Genç, Lisans öncesi öğrenimlerinin ardından Gülhane Askeri Tıp Akademisi'nde başladığı tıp eğitimini  başarıyla tamamlayarak tıp doktoru unvanı almıştır. İhtisasını ise, Gülhane Askeri Tıp Akademisi İç Hastalıkları Ana Bilim Dalı'nda yaparak İç Hastalıkları Uzmanı olmuştur. 

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