The Evaluation of Early Atherosclerosis in Adult Patients with Asthma
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Assessment of Early Atherosclerosis in Asthmatic Patients
This clinical study aims to evaluate the presence of early atherosclerosis in asthmatic patients by measuring carotid intima-media thickness (CIMT). Research indicates that chronic inflammatory conditions like asthma may have systemic effects, and measuring the thickness of the carotid artery walls serves as a critical non-invasive indicator for cardiovascular risks.
Study Methodology and Patient Demographics
The research was conducted at the Muğla Sıtkı Koçman University Medical Faculty Hospital, specifically within the Chest Diseases Polyclinic, between June 2014 and December 2014. The study cohort consisted of 30 asthmatic patients and 30 healthy adults as a control group, all aged between 18 and 30 years.
To ensure the highest level of objectivity, the carotid intima-media thickness measurements were performed by a single specialist radiologist. This specialist remained blinded to the clinical and laboratory data of the participants throughout the evaluation process.
Participant Characteristics
The demographic distribution of the study groups was carefully balanced to ensure statistical accuracy:
- Asthmatic Group: The average age was 23.1±3.8 years, comprising 14 females and 16 males.
- Control Group: The average age was 23.0±4.0 years, comprising 15 females and 15 males.
Comparative Analysis of Carotid Intima-Media Thickness
The findings revealed a clear distinction between the two groups regarding vascular health indicators. The data collected from the measurements are summarized in the table below:
| Group | Average CIMT (mm) | Statistical Significance (p) |
|---|---|---|
| Asthmatic Patients | 0.68 ± 0.022 mm | p < 0.004 |
| Healthy Control Group | 0.58 ± 0.026 mm | p < 0.004 |
Conclusion: Clinical Implications for Asthma and Atherosclerosis
The results of this study demonstrate a statistically significant difference (p < 0.004) between the average carotid intima-media thicknesses of asthmatic and healthy individuals. Specifically, the CIMT was notably increased in patients with asthma compared to the healthy control group.
In conclusion, these findings suggest that increased carotid intima-media thickness serves as a significant marker for early atherosclerosis in asthmatic adults. This study highlights the importance of monitoring vascular health in patients diagnosed with asthma to identify early cardiovascular changes.
