Relationship between hematological parameters and severity of chronic obstructive pulmonary disease

Prof. Dr. Serdar Kalemci
Prof. Dr. Serdar Kalemci
19 Ocak 202384 görüntülenme
Randevu Al
ıNTRODUCTION Chronic obstructive pulmonary disease (COPD) is the most important lung disease lead‑ ing to disability and even death. Recent studies have shown that platelet indices are associated with several cardiovascular diseases; however, data on COPD are scarce. OBJECTIVES We aimed to investigate the relation between the severity of COPD and platelet indices, including the platelet‑to‑lymphocyte ratio (PLR), white blood cell count to mean platelet volume ratio (WMR), and red cell distribution width (RDW). PATIENTS AND METHODS This retrospective study was based on data collected from 153 patients with COPD admitted to our outpatient clinic between March 2014 and March 2015. All participants under‑ went pulmonary function tests, and forced expiratory volume in 1 second, forced vital capacity (FVC), and percentage of FVC expelled in the first second of forced expiration were measured. The population was divided into 4 subgroups according to the severity of COPD: mild, mild to moderate, moderate to severe, and severe. RESULTS We observed a significant increase in platelet distribution width (PDW), mean platelet volume, plateletcrit, PLR, and RDW, and a decrease in WMR with increasing severity of COPD. In a multiple lo‑ gistic regression analysis, PDW and RDW were independently associated with severe COPD. A receiver operating characteristic curve analysis showed that a PDW exceeding 14.85 was associated with severe COPD with a sensitivity of 85% and a specificity of 86%, while an RDW exceeding 14.45 was associated with severe COPD with a sensitivity of 90% and a specificity of 87%. CONCLUSIONS The PDW and RDW are independently associated with disease severity, which may indicate hypoxemia, underlying inflammation, and oxidative stress in COPD.
Relationship between hematological  parameters and severity of chronic obstructive  pulmonary disease

NTRODUCTION Chronic obstructive pulmonary disease (COPD) is the most important lung disease lead‑ ing to disability and even death. Recent studies have shown that platelet indices are associated with several cardiovascular diseases; however, data on COPD are scarce. OBJECTIVES We aimed to investigate the relation between the severity of COPD and platelet indices, including the platelet‑to‑lymphocyte ratio (PLR), white blood cell count to mean platelet volume ratio (WMR), and red cell distribution width (RDW). PATIENTS AND METHODS This retrospective study was based on data collected from 153 patients with COPD admitted to our outpatient clinic between March 2014 and March 2015. All participants under‑ went pulmonary function tests, and forced expiratory volume in 1 second, forced vital capacity (FVC), and percentage of FVC expelled in the first second of forced expiration were measured. The population was divided into 4 subgroups according to the severity of COPD: mild, mild to moderate, moderate to severe, and severe. RESULTS We observed a significant increase in platelet distribution width (PDW), mean platelet volume, plateletcrit, PLR, and RDW, and a decrease in WMR with increasing severity of COPD. In a multiple lo‑ gistic regression analysis, PDW and RDW were independently associated with severe COPD. A receiver operating characteristic curve analysis showed that a PDW exceeding 14.85 was associated with severe COPD with a sensitivity of 85% and a specificity of 86%, while an RDW exceeding 14.45 was associated with severe COPD with a sensitivity of 90% and a specificity of 87%. CONCLUSIONS The PDW and RDW are independently associated with disease severity, which may indicate hypoxemia, underlying inflammation, and oxidative stress in COPD.

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Koah oluşumuKoah tedavisiHemogram lym yüksekliğiKoah hastalığı

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Prof. Dr. Serdar Kalemci

Prof. Dr. Serdar Kalemci

1996 yılında İzmir Eşrefpaşa Lisesi’nden mezun olan Prof. Dr. Serdar KALEMCİ, 2003 yılında Süleyman Demirel Üniversitesi Tıp Fakültesi’nden mezun olmuştur. 2009 yılında Dokuz Eylül Üniversitesi Tıp Fakültesi Göğüs Hastalıkları bölümünden uzmanlığını almıştır. 2010 yılında Şanlıurfa Suruç Devlet Hastanesi’nde mecburi hizmeti tamamladı. 2015 yılında Muğla Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Ana Bilim Dalı’nda çalışırken doçentlik unvanı aldı. Kalemci’nin Göğüs Hastalıkları alanında klinik ve deneysel çalışmaları bulunmaktadır. 50 adet uluslararası yayını bulunmaktadır. Bunlardan 4 tanesi SCI ve 36 tanesi SCI EXPANDED dergilerde yayınlanmıştır. 20 adet ulusal yayını bulunmaktadır. Çok sayıda ulusal ve uluslararası kongrede sözlü ve yazılı bildirisi olmuştur. 2 adet ulusal kongrede ödül, 1 adet uluslararası kongrede ödülü bulunmaktadır. 2 adet projede yürütücü olarak çalışmıştır. 2 adet projede de araştırıcı olarak bulunmuştur.

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